Results 231 to 240 of about 148,726 (288)

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Coexistence of 21-hydroxylase deficiency and Gitelman syndrome in a neonate presenting with severe hyponatremic seizures: a case report. [PDF]

Front Endocrinol (Lausanne)
Zhang R, Zhang Y, Nie Y, Bai Y, Shu J, Liu Y.   +5 more
europepmc   +1 more source

Effects of different iodine supplementation strategies on thyroid function in iodine-deficient pregnant women: a meta-analysis. [PDF]

Front Public Health
Lv Y, Jin B, Guo J, Bu J, Chen C, Han Y, Xie Z, Jia Y, Wan S, Zhang C.   +9 more
europepmc   +1 more source

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THE EFFECT OF POTASSIUM DEFICIENCY ON THE KIDNEY

Pediatrics, 1960
Evidence is presented that the histologic lesion and the defect in urinary concentrating capacity seen in potassium deficiency are a consequence of the potassium deficiency per se and their progression is a function of the duration of the potassium deficiency, not of its severity.
Holliday Malcolm A
exaly   +3 more sources

Physiologic Mechanisms in Potassium Deficiency

New England Journal of Medicine, 1961
ALTHOUGH the older medical literature contains sporadic references to the importance of potassium in certain clinical conditions (as pointed out in the historical review by Gamble1) the modern realization of its importance may be considered to have started with the study of experimental potassium depletion by Heppel.2 Progress followed rapidly with the
A, LEAF, R F, SANTOS
openaire   +2 more sources

POTASSIUM DEFICIENCY IN DIABETIC ACIDOSIS

Journal of the American Medical Association, 1947
Acidosis presents the most dramatic and dangerous of all the complications of diabetes mellitus. That the therapy in diabetic acidosis is unsatisfactory is shown not only in the mortality tables, but in the disagreements that arise whenever the subject is discussed. It is generally conceded that insulin is the prime need.
W M, NICHOLSON, W S, BRANNING
openaire   +2 more sources

POTASSIUM DEFICIENCY IN BULBAR POLIOMYELITIS

Journal of the American Medical Association, 1951
During the past several years there have been an increasing number of reports concerning potassium deficiency in many clinical conditions, including infantile diarrhea,1alkalosis due to intestinal and pyloric obstruction and vomiting,2and in many postoperative patients.3Our studies on potassium metabolism in surgical patients have led us to investigate
H S, LANS, I F, STEIN, R J, BECKER, A L, HOYNE   +3 more
openaire   +2 more sources

The heart in malnutrition and in potassium deficiency

Journal of Chronic Diseases, 1959
Abstract Some patients with edema and other signs of congestive heart failure may have primary or secondary deficiency disorders. For purposes of discussion and description, it is common practice to describe low cardiac output failure, high output failure, left-sided failure, right-sided failure, and whole heart failure.
openaire   +2 more sources

Potassium Deficiency and Vacuolar Myopathy

JAMA: The Journal of the American Medical Association, 1971
ABSTRACT To the Editor.— Oh et al (216:1858, 1971), have again called attention to vacuolar myopathy as one of the rare but dramatic and potentially fatal complications of potassium deficiency. The liberty I have taken in substituting the words "potassium deficiency" for "hypokalemia" is intentional.
openaire   +2 more sources