Results 131 to 140 of about 9,990,243 (194)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Space Potential Fluctuations during MHD Activities in the Compact Helical System (CHS) [PDF]

open access: yes, 1998
Local space potential fluctuations have been measured during MHD activities in a low-beta NBI heated plasma in the Compact Helical System (CHS) by the use of a heavy ion beam probe (HIBP).
Kojima, M.   +20 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Preconception to postpartum accelerometry-based 24-hour movement behaviors: a prospective cohort study

open access: yesBMC Public Health
Background Changes in movement behaviors – physical activity (PA), sedentary behavior, and sleep patterns – across preconception, pregnancy, and postpartum are associated with maternal and child health but remain understudied.
Anne H. Y. Chu   +16 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

INTERDISCIPLINARY ACTIVITY TRAINING IN VIRTUAL ENGINEERING ENVIRONMENT: AN ACTUAL STATE AND PROSPECTS

open access: yesВысшее образование в России, 2017
The paper considers two aspects of the problem of multidisciplinary education: the first, as an effective interaction between business and academic communities to establish a new normative base for qualifications; and the second, as a purely educational ...
V. S. Sheinbaum
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Interactive Electronic Textiles: Technologies, Applications, Opportunities, and Market Potential

open access: yes, 2002
The developing area of interactive electronic textiles is generating an abundance of literature within the textile industry. Presently, researchers in this area are working toward the development of interactive touch and voice activated wireless ...
Meoli, Dina
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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