Results 191 to 200 of about 14,720,292 (299)

Ground water pollution potential of Clark County, Ohio

, 1995
"March, 1995."; Includes bibliographical references (pages 28-34)A ground water pollution potential map of Clark County has been prepared using the DRASTIC mapping process.
Vormelker, Joel D. (Joel David)
core  

Functional role of Nav1.8 channels in action potentials of mouse CGRP-lineage dorsal root ganglion neurons. [PDF]

J Physiol
Osorno T, Stewart RG, Fujita A, Jo S, Bean BP.   +4 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Transient Potential Profiling for Rapid Calcium Ion Quantification: Eliminating Conditioning Time in Solid-Contact Ion-Selective Electrodes. [PDF]

Biosensors (Basel)
Zheng K, Yan C, Jiang M, Lei J, Wang C, Zhao K, Chen D, Guo M.   +7 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients. [PDF]

J Neural Eng
Jensen N, Ly K, Kochnev Goldstein A, Devaud Q, Palanker D.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Notes from the Field: Drug Overdose Deaths in Hotels and Motels - United States, 2022-2024. [PDF]

MMWR Morb Mortal Wkly Rep
Stewart A, Dinwiddie A, Wisdom A, Gilson T.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Voltage compensation of manufacturing errors applied to artificial band gaps in nanoscale transistor. [PDF]

Sci Rep
Aghajani A, Karsenty A.
europepmc   +1 more source