Results 201 to 210 of about 468,716 (263)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The benefits and future potential of generative artificial intelligence (GAI) on mental health: a Delphi study. [PDF]

Int J Qual Stud Health Well-being
Oo CTL, Wider W, Pang NTP, Koh EBY, Vasanthi RK, Thet KZZ, Ramalho R, Özdemir BN, Mahboob K.   +8 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and <i>BAP1</i> loss. [PDF]

Sci Adv
Camp SY, He MX, Cuoco MS, Garza AE, Xirenayi S, Bakouny Z, Saad E, El Masri J, Pimenta E, Meli K, Labaki C, Titchen BM, Kang YJ, Horst J, Trowbridge R, Shannon E, Helvie K, Thorner AR, Vigneau S, Mayorga A, Kodali J, Lachmayr H, Bemus M, Chen P, Deng H, Park J, Choueiri TK, Bi K, Van Allen EM.   +28 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Measurement of urban vitality and the influence mechanism of the built environment on it based on multi-source data: A case study of Yantai City. [PDF]

PLoS One
Zhang Y, Wang X, Wang L, Zhang Y, Ye Y, Jiang H, Chi Y, Liu G, Yao S.   +8 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Co-developing preoperative therapy for Dupuytren's fasciectomy: lived experience and clinical expertise. [PDF]

Res Involv Engagem
Babiker-Moore T, Schurer A, Hughes M, Clark CJ, Crook TB, Kavanagh E.   +5 more
europepmc   +1 more source

The association between perceived 15-minute fitness circle accessibility and physical activity in China: the mediating role of informal social support. [PDF]

Int J Equity Health
Shen Y, Lu C, Ma Y.
europepmc   +1 more source

How perceived environmental quality influences physical activity in urban green spaces? A moderated mediation model. [PDF]

Front Public Health
Zhang P, Lin Y, Zhao B, Ma X, Luo Q, La C.   +5 more
europepmc   +1 more source