Results 251 to 260 of about 542,663 (313)

Reversible and causal epigenetic information loss in liver aging and disease. [PDF]

PNAS Nexus
Shtark RB, Sagy N, Korenfeld N, Gal M, Goldstein I, Bar DZ.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Park green space accessibility and equity for age-friendly urban living in Kunming's central district. [PDF]

Sci Rep
Jiaxin S, Jiansong P.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Impact of artificial intelligence on the availability, accessibility, acceptability and quality of ophthalmic disease screening services: a scoping review. [PDF]

Br J Ophthalmol
Lin S, Zhang J, Jan C, Li L, Peng Y, Qian D, Yin Y, Zhang M, Feng J, He M, Zou H.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Integrating Well-Being in Living and Learning Through Occupational Therapy Fieldwork on a College Campus: The WILL Thrive Program. [PDF]

Behav Sci (Basel)
Brockway SE, Will C, Mendolia M, Keptner K.   +3 more
europepmc   +1 more source

scTELL: a single-cell ATAC-seq tool for locus-specific transposable element identification in chromatin accessibility. [PDF]

Mob DNA
Jeong K, Ha H, Xing J, Choi J, Kim K.
europepmc   +1 more source

Protocol for isolation of nuclei from murine cardiac tissue for single-nucleus multiomic sequencing. [PDF]

STAR Protoc
Veras I, Eken OS, Levy FO, Melleby AO, Aronsen JM.   +4 more
europepmc   +1 more source

Revisiting the Antigen 85 Complex as a Target for Functional Antibody-Based Strategies Against <i>Mycobacterium tuberculosis</i>. [PDF]

Microorganisms
Smekenov I, Tleumbetova N, Bektassov S, Bissenbaev A.   +3 more
europepmc   +1 more source