Results 251 to 260 of about 7,396,179 (293)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Assessment of market potential

A sensitivity analysis will be conducted to determine the robustness of the market opportunities and its susceptibility to change. Another very important aspect of future implementation is the level of perceived risks by potential investors. In this study the main risks of the new components and systems developed will be investigated and communicated ...
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Extractables and Leachables in Pharmaceutical Products: Potential Adverse Effects and Toxicological Risk Assessment. [PDF]

Toxics
Kuzmič S, Zlobec T, Dolenc MS, Roškar R, Lušin TT.   +4 more
europepmc   +1 more source

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Learning Potential Assessment

Special Services in the Schools, 1986
This article describes the foundations and uses of learning potential assessment, a dynamic method of determining the student's capacity for cognitive modifiability. The method, which forms the basis for the Learning Potential Assessment Device (LPAD), can assist in identifying low functioning students whose capacity for greater achievement typically ...
Reuven Feuerstein, Yaacov Rand, Mogens Jensen, Shlomo Kaniel, David Tzuriel, Nili Ben Shachar, Yael Mintzker   +6 more
openaire   +1 more source

Assessment of Rehabilitation Potential

Clinics in Geriatric Medicine, 1993
Physicians often have a powerful influence on patients and their families. If we enthusiastically recommend a realistic rehabilitation program, it will help our patients face the arduous process of functional recovery. Rehabilitation potential depends on many factors.
openaire   +2 more sources

Assessing employee potentials for abuse

Journal of Clinical Psychology, 1983
Attempted to develop a battery of questionnaires and demographic data capable of early identification of institutional caretakers with potential for abuse of a client. After an extensive literature review on institutional client abuse, it was determined that the Child Abuse Potential Inventory, Minnesota Satisfaction Questionnaire and a General ...
M D, Haddock, W M, McQueen
openaire   +2 more sources

Assessing Potentially Violent Extremists

2021
This chapter describes the way investigative psychologists of the Dutch National Police assess behavior of potentially violent extremists. Investigative psychologists in the Netherlands have adopted structured professional judgment as the best framework to do so.
Lieke Bootsma, Ellen Harbers
openaire   +1 more source

Preclinical Abuse Potential Assessment

2015
Although laboratories have been conducting scientific evaluations of the abused drugs for many years, preclinical evaluations of the abuse potential of new drugs have been an integral component of new drug applications more recently. The development of a unified testing approach is crucial prior to initiating individual studies to address abuse ...
openaire   +2 more sources