Results 81 to 90 of about 9,094,493 (295)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Assessing the impact of climate change on the potential distribution of Keteleeria evelyniana Mast. in southwest China: a Maxent modeling approach

Frontiers in Plant Science
Keteleeria evelyniana Mast., which is widespread in southwestern China, is valuable for studying under different future climate scenarios to assess potential distribution shifts in response to climate warming.
Yuan Feng, Yuan Feng, Yuan Feng, Guanghui Dai, Guanghui Dai, Guanghui Dai, Hua Li, Yong Chai, Yong Chai, Yong Chai, Rui Bao, Meng Wang, Chunlin Luo, Yangping Qin, Yangping Qin   +14 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluation of Spatial Distribution of Pulse Blue Butterfly (Lampides boeticus), Pest of Legume Crops, in Response to Climate Change

Insects
The potential distribution of the pulse blue butterfly, Lampides boeticus (Lepidoptera: Lycaenidae), was determined using MaxEnt, random forest, and ensemble models.
Jeong Ho Hwang, Sunhee Yoon, Wang-Hee Lee   +2 more
doaj   +1 more source

Fitting a mass distribution to a potential [PDF]

Fitting mass distribution to gravitational potential, for simulating lunar ...
Levie, S. L., Jr.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Modeling the Future of a Wild Edible Fern Under Climate Change: Distribution and Cultivation Zones of Pteridium aquilinum var. latiusculum in the Dadu–Min River Region

Plants
Under the pressures of global climate change, the sustainable management of plant resources in alpine gorge regions faces severe challenges. P. aquilinum var.
Yi Huang, Jingtian Yang, Guanghua Zhao, Zixi Shama, Qingsong Ge, Yang Yang, Jian Yang   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Assessment of the Impact of Climate Change on the Potential Distributions of Melliferous Plant Species on the Yucatan Peninsula, Mexico: Implications for Conservation Planning

Conservation
Climate change is altering environmental conditions, which can, in turn, change the geographic distribution and flowering patterns of plant species, affecting both the plants themselves and their pollinators. The responses of melliferous plant species to
José Luis Aragón-Gastélum, Jorge E. Ramírez-Albores, Marlín Pérez-Suárez, Jorge Albino Vargas-Contreras, Francisco Javier Aguirre-Crespo, F. Ofelia Plascencia-Escalante, Annery Serrano-Rodríguez, Alexis Herminio Plasencia-Vázquez   +7 more
doaj   +1 more source