Results 111 to 120 of about 6,432,733 (292)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
DEVELOPMENT OF A GRAVITATIONAL AND PENDULUM SOLAR TRACKER FOR STANDALONE PHOTOVOLTAIC PANELS [PDF]
Engenharia AgrícolaThe contribution of photovoltaic energy has steadily increased within the energy matrix worldwide. Within this renewable energy system, optimization is there is continually pursued, which can be achieved through various approaches, including advancements
Jorge A. Wissmann +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Remarks on equilibrium potential and energy [PDF]
Annales de l'Institut Fourier, 1975 This note discusses to problem of the minimization of energy by the equilibrium measure obtained by the method of last exit in reference Ann. Inst. Fourier, 23-3 (1973), 313–322.
openaire +2 more sources
No Strings Attached: Potential vs. Interaction Energy In QCD [PDF]
, 1996 In infrared-stable fixed-point field theories, the interaction energy of a test particle is proportional to the non-relativistic (heavy source) coordinate-space potential derived from the field strength produced by that source.
Goldman, T.
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Study of Some Thorium Isotopes near to the Closed Shell (82 and 126)
Engineering ProceedingsUsing the interacting bosons model-one (IBM-1), the nuclear structure of the thorium isotopes 224Th, 226Th, and 228Th were examined in this study, which are near from closed shell 82 and 126.
Nibras Hayder Hammood Eatiah +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source