Results 121 to 130 of about 15,010,208 (306)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

GERMANIUM MONOCHLORIDE (GECL) - SPECTROSCOPIC CONSTANTS AND POTENTIAL-ENERGY CURVES

open access: yes, 1993
The electronic states, potential energy curves and spectroscopic properties of the GeCl radical were calculated by means of the relativistic ab initio complete active space multiconfiguration self-consistent field (CASSCF) followed by first- and second ...
LIAO,DW, BALASUBRAMANIAN,K, 廖代伟
core  

Potential energy curves of the quasi-stable states of CO2+ determined using Auger spectroscopy

open access: yes, 2007
Observations of Auger transitions to quasi-stable states of CO{++} subsequent to C_1s{-1} and O_1s{-1} ionizations of CO are presented along with the corresponding photoelectron spectra and calculations of the potential energy curves.
M Hoshino   +9 more
core   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova   +9 more
wiley   +1 more source

Theoretical study of highly-excited states of KRb molecule

open access: yesOpen Physics, 2013
Łobacz Piotr   +2 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

Energy savings and greenhouse gas mitigation potential in the Swedish wood industry

open access: yes, 2019
Improving energy efficiency in industry is recognized as one of the most crucial actions for mitigating climate change. The lack of knowledge regarding energy end-use makes it difficult for companies to know in which processes the highest energy ...
Johnsson, Simon,   +7 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

open access: yesArthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos   +2 more
wiley   +1 more source

Energy of Photons in Expanding Spacetime: Comparing FLRW and Conformal Cosmology Metrics

open access: yesGalaxies
We investigate the behaviour of photons in Riemann spacetime, focusing on how their velocity and energy are affected by cosmic expansion. Specifically, we examine the differences in energy conservation depending on the cosmological model.
Václav Vavryčuk
doaj   +1 more source

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