Results 191 to 200 of about 4,979,212 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Exploring the potential function of high expression of <i>ANAPC1</i> in regulating ubiquitination in hepatocellular carcinoma. [PDF]

World J Gastrointest Oncol
Tang YX, Wu WZ, Zhou SS, Zeng DT, Zheng GC, He RQ, Qin DY, Huang WY, Chen JT, Dang YW, Tang YL, Chi BT, Zhan YT, Chen G.   +13 more
europepmc   +1 more source

Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study. [PDF]

PLoS One, 2023
Li K, Wang H, Yang C, Li C, Xue B, Zhou J.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Potential Function-Based Molecular Dynamics Simulation of Al-Cu-Li Alloys and Comparison with Experiments. [PDF]

Materials (Basel)
Chen F, Wang H, Liu Y, Qi L, Zeng Q.
europepmc   +1 more source

Identification and Evolutionary Analysis of Cotton (Gossypium hirsutum) WOX Family Genes and Their Potential Function in Somatic Embryogenesis. [PDF]

Int J Mol Sci, 2023
Sun R, Zhang X, Ma D, Liu C.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Retracted: The Potential Function of Super Enhancers in Human Bone Marrow Mesenchymal Stem Cells during Osteogenic Differentiation. [PDF]

Biomed Res Int, 2023
International BR.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Ganglioside structure, function, and biomedical potential [proceedings of the Symposium on Ganglioside Structure, Function, and Biomedical Potential, held July 6 - 10, 1983, at Parksville, Vancouver Island, British Columbia, Canada] [PDF]

, 1984
Ledeen, Robert W., Symposium on Ganglioside Structure, Function, and Biomedical Potential 1983 Parksville, British Columbia   +1 more
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