Results 31 to 40 of about 8,991,315 (281)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
What is an organism? An immunological answer [PDF]
, 2010 The question “What is an organism?”, formerly considered as essential in biology, has now been increasingly replaced by a larger question, “What is a biological individual?”.
Pradeu, Thomas
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Organism in Developmental System Theory (DST) [PDF]
, 2009 In this paper, I address the question of what the Developmental Systems Theory (DST) aims at explaining. I distinguish two lines of thought in DST, one which deals specifically with development, and tries to explain the development of the individual ...
Pradeu, Thomas
core
Development of entomotoxic molecules as control agents: illustration of some protein potential uses and limits of lectins (Review) [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2010 Worldwide use of pesticide has dramatically increased during the last two decades, which are known to cause a lot of problems to both environment and human health.
Jaber, K., Haubruge, E., Francis, F.
doaj
Egyptian Journal of Biological Pest Control, 2022 Background The biological diversity on planet earth is declining day by day, due to different factors such as excessive applications of pesticides. The utilization of chemical pesticides affected environment as well as microorganisms. The awareness among
Preety Tomar +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Designing synthetic communities with organism-free modular computational models [PDF]
, 2022 Synthetic biology designs and constructs new biological parts, devices and systems with predetermined functionalities. With the unlimited ability to synthesise any DNA and RNA and transfer it to almost any organism, we are at the dawn of a new era in ...
Anna, Matuszyńska +4 more
core +1 more source
Marchantia polymorpha as a model plant in the evolutionary study of plant-microorganism interactions
Current Plant Biology, 2020 Marchantia polymorpha is a common liverwort found naturally in different parts of the world. Due to its easy handling in the laboratory and its life cycle with a haploid phase, it is increasingly used as a model organism for physiological, metabolic and ...
Jorge Poveda
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source