Results 121 to 130 of about 1,786,583 (270)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

How fractional counting affects the Impact Factor: Normalization in terms of differences in citation potentials among fields of science

, 2010
The ISI-Impact Factors suffer from a number of drawbacks, among them the statistics-why should one use the mean and not the median?-and the incomparability among fields of science because of systematic differences in citation behavior among fields. Can these drawbacks be counteracted by counting citation weights fractionally instead of using whole ...
Leydesdorff, Loet, Bornmann, Lutz
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Diurnal variation of the distance between cranium and the third lumbar vertebra and its implications for craniospinal irradiation

Physics and Imaging in Radiation Oncology
The spine shortens during the day because of gravity. This study quantified the effect of treatment fraction timing on spinal length in 13 craniospinal irradiation patients.
Annele Heikkilä, Maija Rossi, Antti Vanhanen, Tuomas Koivumäki, Michiel Postema, Eeva Boman   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Investigating carbide characteristics effect on multiscale mechanical behavior of AISI 420 steel using crystal plasticity simulation

Journal of Materials Research and Technology
Understanding the impact of precipitates on the mechanical behavior of material is crucial for effective material design and application. This research focuses on AISI 420 stainless steel, characterized by a ferritic matrix with dispersed carbides in its
Kegu Lu, Yadong Zhou, Soheil Solhjoo, Maysam Naghinejad, Redmer van Tijum, Yutao Pei, Jan Post   +6 more
doaj   +1 more source

Do Better Customers Utilize Electronic Distribution Channels: The Case of PC Banking [PDF]

Firms are increasingly implementing electronic distribution strategies to augment existing physical infrastructure for product and service delivery.
Frances X. Frei, Lorin M. Hitt
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Simulation Analysis of the Leakage and Diffusion Risk of a Hydrogen Storage System in Hydrogen Aircraft

Aerospace
Hydrogen is an alternative energy source for the aviation industry due to its renewability and cleanliness, although this novel application needs to be reassessed for the potential leakage risk.
Xiangjun Dang, Mingwen Zhong, Wei Jia, Xiaojun Yang, Haoming Liu, Yongxuan Shao, Zhe Yang   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source