Results 131 to 140 of about 14,945,351 (305)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Automated in-situ calibrations at the Curie temperature of ferroelectric materials [PDF]

At industrial process conditions, the reading of thermometers can change or drift over time. To reduce the risk of having such undetected errors in the measurement, thermometers can be recalibrated periodically off-process, which is an elaborate and ...
Schalles, Marc, Vrdoljak, Pavo
core   +1 more source

Studies on the embryonic development and larval infection potential of the stomach bot flies, Gasterophilus pecorum

International Journal for Parasitology: Parasites and Wildlife
Endangered Przewalski's horses have faced severe infections from Gasterophilus pecorum (Diptera, Gastrophilidae) in Xinjiang's Kalamaili Nature Reserve (KNR). This study examines G.
Yu Zhang, Ke Zhang, Meng Wang, Xiaojia Wu, Jiawei Liu, Hongjun Chu, Dong Zhang, Kai Li, Heqing Huang   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Ta-Ni-braze for high temperature stable ceramic - ceramic junctions

, 2022
S.54-58Ceramic materials are widely used for high temperature applications. It is still a challenge to produce ceramicceramic or ceramic-metal junctions which are stable at temperatures above 1000 °C using metallic brazes.
Martin, H.-P., Triebert, A., Matthey, B.
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Oxygen potential in cast irons – A thermodynamic discussion on the influence of temperature and Mg treatment

The activity of dissolved oxygen in cast irons affects the solidification behaviour, for example, the surface/interfacial tension will be influenced, and as a consequence, the graphite morphology and nodularity will be influenced.In the present study ...
Ekengård, Johan,, Diószegi, Attila,, Matsushita, Taishi,   +2 more
core  

Charmonium correlation and spectral functions in quenched lattice QCD at finite temperature [PDF]

, 2010
Ding H. Charmonium correlation and spectral functions in quenched lattice QCD at finite temperature. Bielefeld (Germany): Bielefeld University; 2010.In this thesis, we have investigated the properties of charmonium states at finite temperature in ...
Ding, Hengtong
core