Results 131 to 140 of about 19,878,416 (347)
Non-Archimedean Kelvin Transformation
Математичні СтудіїWe introduce and study an analog of the Kelvin transformation connected with the Vladimirov-Taibleson operator acting on real- or complex-valued functions on a space $K^n$ over a non-Archimedean local field $K$.
A. V. Antoniouk, A. N. Kochubei
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A magnetically induced quantum critical point in holography
, 2016 We investigate quantum critical points in a 2+1 dimensional gauge theory at finite chemical potential χ and magnetic field B. The gravity dual is based on 4D NN = 2 Fayet-Iliopoulos gauged supergravity and the solutions we consider — that are constructed
Papadoulaki, O. +5 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Eigenvalues in potential theory
, 1988 Hansen W, Hueber H. Eigenvalues in potential theory. Journal of Differential Equations.
Hansen, W, Hueber, H, Hansen, Wolfhard
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, 1981 In this chapter we will introduce the reader to the techniques of the Boundary Element Method applied to simple Laplacian problems. Most classical applications refer to electrostatic and magnetic fields, but the Laplacian operator also governs problems such as Saint-Venant torsion, irrotational flow, fluid flow through porous media and the added fluid ...
París Carballo, Federico +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
EXPLORATION OF SELF-MONITORING AS A THEORY-DRIVEN MANAGEMENT APPROACH FOR CHRONIC PAIN
, 2014 Theory is often recommended as a framework for guiding hypothesized mechanisms of effect. There is limited guidance about how to use theory in intervention development. We used two novel approaches to explore theory as a framework to guide intervention
Tougas, Michelle
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source