Results 181 to 190 of about 19,878,416 (347)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Critical Theory and Libertarian Socialism Realizing the Political Potential of Critical Social Theory

, 2016
This volume in the Critical Theory and Contemporary Society series examines the role critical theory plays in today's political, social, and economic crises, showing how it can help to both diagnose and remedy such ...
Masquelier, C
core  

Development of a Theory-Based Nutrition Education Program Targeting Varsity Athletes at a Canadian University. [PDF]

Nutrients
Daher J, Haines J, Mountjoy M, El Khoury D.   +3 more
europepmc   +1 more source

Foundations of potential theory

Mathematical Gazette, 1934
O. D. Kellogg
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Is involution effective? Research on the influence mechanism of perceived overwork climate on employees' creative performance. [PDF]

Front Psychol
Chen Y, Zhou M, Du P, Song K, Sun Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A potential theoretic approach to twisting

, 2005
This paper introduces a geometric, potential theoretic approach to the study of twist point in the boundary of a planar domain. It introduces a map h from a domain D to harmonic functions such that, when z tends to a boundary point w, the limit behaviour
Arcozzi, N, Di Biase, F, PICARDELLO, ANGELO MASSIMO, Casadio Tarabusi, E, Picardello, AM, Casadio-Tarabusi, E   +5 more
core  

On the Open TS/ST Correspondence. [PDF]

Commun Math Phys
François M, Grassi A.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source