Results 181 to 190 of about 20,699 (254)

Network meta‐analysis of tocolytics in preterm labor: Establishing an evidence‐based treatment hierarchy

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background The choice of tocolytic drugs is one of the most debated aspects of preterm birth management. Objective This network meta‐analysis aimed to establish an evidence‐based hierarchy for tocolytics used in preterm labor by evaluating their efficacy in delaying delivery, safety, and neonatal outcomes.
Barbara Gardella   +5 more
wiley   +1 more source

Therapeutic orphans no more: Revisiting the ethical justification for excluding pregnant women from pharmaceutical clinical trials

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract For six decades, pregnant women have been routinely excluded from pharmaceutical clinical trials, a practice rooted in a protectionist ethic that emerged after the thalidomide tragedy. This narrative review examines whether that exclusion remains ethically justifiable, drawing on the obstetric, pharmacological, and bioethical literature ...
Camila Kruger Cabar   +1 more
wiley   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

open access: yesiMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu   +7 more
wiley   +1 more source

Solidarity With Planet Earth: Predictors of Pro‐Environmental Behavior Among Adolescents and Young Adults

open access: yesJournal of Adolescence, EarlyView.
ABSTRACT Introduction Conceptualizing pro‐environmental behavior (PEB) as solidarity with planet Earth and as a socio‐ecological dilemma, it is argued that PEB results when humans prioritize positive long‐term consequences for the entire planet over positive short‐term individual gains. Therefore, it was tested whether four socio‐cognitive competencies
Dagmar Strohmeier   +2 more
wiley   +1 more source

Adverse Drug Reaction Trajectories in Older Adults: From Pharmacological Vulnerability to Clinical Complexity. [PDF]

open access: yesInt J Environ Res Public Health
Lauretani F   +6 more
europepmc   +1 more source

No Apologies? The Role of Apology for Structural‐Historical Injustice

open access: yesJournal of Applied Philosophy, EarlyView.
ABSTRACT During this era of political apologies, a new literature has emerged in historical injustice interrogating the relationship between structural and historical injustice, with various theories conceptualising the relationship in different ways. Interestingly, ‘apology’ rarely appears in this literature.
Maeve McKeown
wiley   +1 more source

Trustworthy AI Is Not Valuable

open access: yesJournal of Applied Philosophy, EarlyView.
ABSTRACT ‘Trustworthy AI’ is a buzzword in AI research, with scores of scholars discussing whether AI systems can be trustworthy. This demand for trustworthy AI is intuitive, especially when AI is used in healthcare or criminal law, where the stakes are incredibly high. In this article, I push back on calls for trustworthy AI.
James Edgar Lim
wiley   +1 more source

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