Results 211 to 220 of about 1,873,177 (302)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Associations of potentially inappropriate medications in older adults with mortality and hospitalizations: methodological challenges in pharmacoepidemiology. [PDF]

Eur J Epidemiol
Degen M, Schöttker B.
europepmc   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Medication Use Patterns, Polypharmacy, and Potentially Inappropriate Medications among Institutionalized Older Adults in East Coast Malaysia: A Cross-sectional Study. [PDF]

J Res Pharm Pract
Ismail A, Mustafa BE, Mohd FN, Musa MFC, Mustafa NS, Mokhtar KI, Ardini YD, Abdul Qader OAJ.   +7 more
europepmc   +1 more source

Potentially Inappropriate Medications, Frailty, and Outcomes in Patients With Cancer Managed in a National Health Care System. [PDF]

J Natl Compr Canc Netw
La J, Hshieh T, Hamparsumian A, Zwolinski R, Wood J, Dharne M, Gaziano JM, Brophy MT, Do NV, Munshi NC, Driver JA, Abel GA, Fillmore NR, DuMontier C.   +13 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Study protocol for a hybrid I randomised clinical trial to evaluate an audit and feedback and a pharmacist-led intervention to reduce potentially inappropriate medications in older adults: the AIM study. [PDF]

BMJ Open
Leiva A, Gallardo Alfaro L, Bejarano F, Sempere E, Soler A, Huguet A, Llarena M, Lekue I, Campabadal Prats C, Salom C, Solaz RB, Socias Cañellas C, Gonzalez A, Campins GM, Vanrell A, Rovira M, Ponsa Mir G, Vicens-Caldentey C, AIM Group.   +18 more
europepmc   +1 more source

Safety concerns reported by coroners following fentanyl patch fatalities in England, Wales and Northern Ireland between 1997 and 2024

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To identify safety concerns reported by coroners following fentanyl patch‐related deaths in England, Wales and Northern Ireland, and determine differences in coronial reporting. Methods A systematic case series linking the National Programme on Substance Use Mortality (NPSUM) and the Preventable Deaths Tracker (PDT) (https ...
Eman Mshari, Caroline S. Copeland, Georgia C. Richards   +2 more
wiley   +1 more source

Association Between Frailty and Use of Potentially Inappropriate Medications in Elderly Hospitalized Patients: A Cross-Sectional Study. [PDF]

In Vivo
Morisaki Y, Maeda-Minami A, Sato M, Izumi S, Suzuki M, Funakoshi R, Mano Y.   +6 more
europepmc   +1 more source