Results 61 to 70 of about 33,646 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Factor Capitalization,Industry Development and Targeted Poverty Alleviation——Based on the Investigation of Danzhai County,Guizhou Province

open access: yesContemporary Social Sciences, 2018
At present, targeted poverty alleviation is a major development strategy in China. Based on the investigation of Danzhai County in Guizhou Province, this paper argues that industry development is the fundamental measure through which to implement the ...
Zhang Haipeng
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Research on the Model of E-commerce Precision Poverty Alleviation Based on the Universities

open access: yesSHS Web of Conferences, 2019
The model of e-commerce precision poverty alleviation based on the universities emphasizes the important role of the combination of university platforms and e-commerce in precision poverty alleviation. It aims to solve the problems of talent shortage and
Liu Xiyu, Wang Yisheng, Zheng Shi
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Realize Facilitated Targeted Poverty Elimination with Targeted Poverty——Alleviation: A New Anti-Poverty Approach for Rural China

open access: yesContemporary Social Sciences, 2017
Since the Reform and Opening-up, remarkable achievements in poverty alleviation have been made in China. China’s success in mass poverty reduction can be attributed to its rapid economic growth, large-scale regional poverty alleviation and development ...
Wang Sangui
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Empowering the Poor through Decentralization : Brazil Rural Poverty Alleviation Program

open access: yes, 2001
The Rural Poverty Alleviation Program in Northeast Brazil uses an integrated approach to social and economic analysis in tackling poverty at the community level. Key to the success of this program is the use of
Kuehnast, Kathleen
core   +1 more source

New Approaches to Targeted Poverty Alleviation in the Age of Big Data——On Improving the Results of Targeted Poverty Alleviation Programs(10)

open access: yesContemporary Social Sciences, 2018
Since the State Council issued the Action Plan on Promoting the Development of the Big Data Industry,big data-enabled information integration and processing applications have increasingly become the basic strategic resources for the building of a modern ...
Mo Guanghui
doaj   +1 more source

Study on the Relationship between Financial Development and Poverty Alleviation in Guizhou Province Based on Kuznets Curve [PDF]

open access: yesJournal of Risk Analysis and Crisis Response (JRACR), 2018
Based on the construction of the nonlinear effect model of financial poverty alleviation, the paper used Granger causality test and regression analysis to analyze the relationship between financial development and poverty alleviation in Guizhou province.
Jianchun Yang, Chaochao Liang
doaj   +1 more source

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