Results 101 to 110 of about 1,000,650 (308)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Pobreza: ¿Una salida del túnel?

open access: yesApuntes del CENES, 2008
El artículo discute la manera de estudiar la pobreza, principalmente en los países atrasados y, en particular, en América Latina. Las formas de medición a las que conduce una conceptualización nueva sobre este fenómeno, plantea, también, nuevas formas ...
Pierre Salama
doaj  

Relationship between Income-poverty and Food insecurity in Rural Far-western Mid-hills of Nepal [PDF]

open access: yes
For the purpose of this study, sample was selected through stratified random sampling from Baitadi district, which falls in rural Far-western Hills of Nepal.
Joshi, Niraj Prakash   +1 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Social Policy Trends: What Does The Poverty Line Measure?

open access: yesThe School of Public Policy Publications
The federal government identifies who is experiencing poverty by comparing household incomes to a measure called the Poverty Line. What does this poverty line measure? Lifting people out of poverty is an important public policy goal.
Ronald Kneebone, Margarita Wilkins
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Modern approaches to studying the phenomenon of poverty

open access: yesУченые записки Российской академии предпринимательства, 2021
The article is devoted to the main modern approaches and interpretations of the concept of poverty. Various types of poverty and categories of poor people are considered, the main causes of poverty are shown.
D. A. Popravko
doaj  

Quantifying the magnitude and severity of absolute poverty in the developing world in the mid-1980s [PDF]

open access: yes
In counting the poor, and measuring the severity of absolute poverty, one faces a number of difficult questions. What poverty line should be used? Should one use the same poverty line across all countries?
Chan, Elaine   +3 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy