Results 91 to 100 of about 6,601,594 (352)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Individual Analysis of Multidimensional Gender-based Poverty in Kepulauan Riau Province
Jurnal Nuansa AkademikPoverty has become a problem that always existed in various regions include Kepulauan Riau Province. This study aims to examine gender-based multidimensional poverty in Kepulauan Riau Province through the identification of the forming factors and the ...
Dhia Fauzia Rahman +2 more
doaj +1 more source
Poverty Eradication Dilemma: Understanding Poverty Dynamics in Nebbi District, Uganda [PDF]
, 2008 This paper addresses a current methodological gap in poverty measurement, which stems from acknowledging the multi-dimensionality of poverty, on the one hand, and using an income/consumption measurement of poverty as thenorm, on the ...
Alfred Lakwo
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Understandings and Misunderstandings of Multidimensional Poverty Measurement [PDF]
Multidimensional measures provide an alternative lens through which poverty may be viewed and understood. In recent work we have attempted to offer a practical approach to identifying the poor and measuring aggregate poverty (Alkire and Foster 2011).
Sabina Alkire and James Foster
core
New directions in the analysis of inequality and poverty [PDF]
, 2007 Over the last four decades, academic and wider public interest in inequality and poverty has grown substantially. In this paper we address the question: what have been the major new directions in the analysis of inequality and poverty over the last ...
Jenkins, Stephen, Micklewright, John
core +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
African Evaluation Journal, 2014 Poverty is increasingly recognised as a multidimensional phenomenon in the development literature, encompassing not only income, but also a range of factors related to broadening an individual’s freedoms to live a life of their own choosing.
Heath Prince
doaj +1 more source
US Poverty Studies and Poverty Measurement: The past 25 years [PDF]
This paper discusses the contribution made by American social scientists to the study of poverty in the past twenty five years. It has three parts.
Howard Glennerster
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source