Results 91 to 100 of about 98,133 (216)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Breaking the chains of poverty: examining the influence of smartphone usage on multidimensional poverty in rural settings

open access: yesHumanities & Social Sciences Communications
We analyze the impact of smartphone usage on multidimensional poverty reduction. Utilizing the A-F approach, we compute a multidimensional poverty index based on five dimensions: education, health, income, living standard, and labor force.
Xian Liang   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A system dynamics model on how zakat can reduce poverty in Indonesia

open access: yesJurnal Ekonomi dan Keuangan Islam
Purpose – This study analyzes the potential of zakat for poverty alleviation using a system dynamics approach. Indonesia has excellent zakat potential as a country with the largest Muslim population.
Danang Setiawan   +2 more
doaj   +2 more sources

The nexus between poverty reduction and carbon emissions: Insights from Hubei, China during the Targeted Poverty Alleviation Period

open access: yesGeography and Sustainability
Wiping out poverty while controlling carbon emissions is a major challenge of our time. China eradicated extreme poverty in 2020 through the targeted poverty alleviation (TPA) strategy, providing a unique case to examine the poverty-carbon nexus at the ...
Mengxiao Liu, Yong Ge
doaj   +1 more source

Home - About - Disclaimer - Privacy