Results 121 to 130 of about 98,133 (216)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Farm size limits agriculture's poverty reduction potential in Eastern India even with irrigation-led intensification. [PDF]

Agric Syst, 2023
Urfels A, Mausch K, Harris D, McDonald AJ, Kishore A, Balwinder-Singh, van Halsema G, Struik PC, Craufurd P, Foster T, Singh V, Krupnik TJ.   +11 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Poverty-reduction interventions combined with psychological interventions: A systematic literature review. [PDF]

Sci Rep
Tanski M, Wei D, Singh S, Pabon MA, Bahure VK, Jordans MJD, Lund C, Roy S, Singh R, Thapa A, Tol WA, Evans-Lacko S.   +11 more
europepmc   +1 more source

Does Social Medical Insurance Achieve a Poverty Reduction Effect in China? [PDF]

Front Public Health, 2021
Sun JL, Tao R, Wang L, Jin LM.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Multidimensional poverty reduction effect of climate smart agriculture practices among rural households in Siltie Zone, Central Ethiopia. [PDF]

PLoS One
Shifa JY, Tsehay AS.
europepmc   +1 more source

The impact of a poverty reduction intervention on infant brain activity. [PDF]

Proc Natl Acad Sci U S A, 2022
Troller-Renfree SV, Costanzo MA, Duncan GJ, Magnuson K, Gennetian LA, Yoshikawa H, Halpern-Meekin S, Fox NA, Noble KG.   +8 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Combining self-regulation and poverty reduction to prevent depression and anxiety among adolescents experiencing multi-dimensional poverty in Colombia, Nepal and South Africa: study protocol of a pilot 4-arm cluster randomised controlled trial. [PDF]

Pilot Feasibility Stud
Jordans MJD, Lund C, Garman EC, Bonifaz MS, Avendano M, Bauer A, Dedios Sanguineti MC, Eleftheriou G, Evans-Lacko S, Jaramillo SG, García JF, Gautam K, Gevonden M, Jacobs R, Kohrt BA, Krabbendam L, Luitel NP, van der Merwe N, Piedrahita JJC, Singh R, Sinichi M, Trujillo D, Sorsdahl K, Roy S, Tol WA, Rojas D, Yarrow P.   +26 more
europepmc   +1 more source