Results 61 to 70 of about 98,133 (216)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The impact of contract farming on household income and poverty alleviation: Insights from smallholder poultry farmers in arid and semi-arid regions of Kenya

Agricultural Economics (AGRICECON)
This study explores the impact of contract farming on household income and rural poverty alleviation using measures outlined by World Bank among 410 smallholder Kenyan poultry farmers.
Emmanuel Kiprop, Jane Chelagat, Geng Xianhui, Gershom Endelani Mwalupaso, Kebebew Bezu, Salman Ibn Yasin   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Causal relationship between FDI and poverty reduction in South Africa

Cogent Economics & Finance, 2017
This study investigates the causal relationship between poverty reduction and foreign direct investment (FDI) inflows in South Africa using time-series data from 1980 to 2014.
M.T. Magombeyi, N.M. Odhiambo
doaj   +1 more source

Poverty Reduction Issues: Village Economy Perspective

Asian Development Review, 2002
Since land and human capital are the two most important resources in rural areas, it is essential to increase the amount of land and human capital owned by the poor and to increase wage rates for them by increasing labor demand, in order to reduce rural ...
Keijiro Otsuka
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Exploring honey-derived compounds as potential inhibitors of NDRG1 for breast cancer treatment under hypoxic conditions: a multiomics profiling, molecular docking, and molecular dynamics study

Future Journal of Pharmaceutical Sciences
Background Hypoxia has been recognized as a major contributor to cancer progression. Targeting hypoxia-derived factors, particularly in breast cancer, may present an auspicious strategy for cancer therapy. Honey-derived natural products have demonstrated
Wira Eka Putra, Arief Hidayatullah, Diana Widiastuti, Muhammad Fikri Heikal, Sustiprijatno Sustiprijatno   +4 more
doaj   +1 more source

Exploring the Rural Revitalization Effect under the Interaction of Agro-Tourism Integration and Tourism-Driven Poverty Reduction: Empirical Evidence for China

Land
Under the robust impetus of China’s rural revitalization strategy, agro-tourism integration and tourism-driven poverty reduction have profoundly impacted various aspects of China’s economy, society, and ecology. This has propelled coordinated urban–rural
Debin Ma, Dongqi Sun, Ziyi Wang
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source