Results 41 to 50 of about 25,369 (231)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Effect of Povidone Iodine and Hydrogen Peroxide on Fracture Healing: A Histomorphometric Study on Rats

Journal of Orthopaedic Surgery, 2016
Purpose To evaluate the effect of povidone iodine and hydrogen peroxide on fracture healing in a rat model. Methods The middle section of the right femur of 36 male Sprague Dawley rats was osteotomised with a saw.
Kurniadi Husodo, Achmad Fauzi Kamal, Achmad Aulia Yusuf   +2 more
doaj   +1 more source

Meta-analysis of the efficacy of preoperative skin preparation with alcoholic chlorhexidine compared to povidone iodine in orthopedic surgery

Scientific Reports, 2021
Preoperative skin preparation is an effective method to prevent surgical site infections (SSI). Alcoholic chlorhexidine (CHG) and povidone iodine (PV-I) are the most widely used antiseptic agents.
Mario Mastrocola, Georg Matziolis, Sabrina Böhle, Chris Lindemann, Peter Schlattmann, Henk Eijer   +5 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Comparison the therapeutic effects of henna, procaine penicillin and povidone-iodine solutions as uterine flushings in Iraqi Arabian mares

Kufa Journal for Veterinary Medical Sciences, 2017
In the last decade, many researchers tried herbal medicine due to its beneficial therapeutic effects by less side effects, so our study is conducted on (12) Iraqi Arabian mares to compare the therapeutic effect of henna 20% with procaine penicillin and ...
Masar S. Kadhim
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Perbandingan Efektifitas Larutan Antiseptik Kombinasi Chlorexidine Gluconate Cetrimide - Alkohol 70% Dengan Povidone Iodine 10 % Terhadap Kepadatan Kuman Pada Tindakan Anestesi Spinal

JAI (Jurnal Anestesiologi Indonesia), 2015
Latar belakang : Infeksi bakteri dapat disebabkan oleh tehnik neuraxial. Salah satu faktor penyebab  infeksi bakteri adalah  peralatan yang digunakan, tehnik aseptik yang salah, atau larutan anti septik yang dipakai.
Khadafi Indrawan, Wiwi Jaya, Noorhamdani Noorhamdani   +2 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Copper-amino acid/Carboxymethyl starch composite for controllable releasing of povidone-iodine

BMC Chemistry
Povidone-iodine is identified as one of the widely applicable antiseptic reagents for treatment of skin infection and wound healing. Controllable releasing of povidone-iodine is extensively required for healing of chronic wounds.
Moataz Morad, Seraj O. Alzahrani, Albandary Almahri, Ibrahim S. S. Alatawi, Kamelah S. Alrashdi, Kholood M. Alkhamis, Hatun H. Alsharief, Nashwa M. El-Metwaly   +7 more
doaj   +1 more source