Results 51 to 60 of about 16,429,906 (357)
Prey selection of lions Panthera leo in a small, enclosed reserve
Annual trends in numbers of ungulate species on a 15 km² reserve from 1993 to 1998, were evaluated in the context of lion Panthera leo reintroduction during 1996, and subsequent predation by them.
R.J. Power
doaj
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Sex differences in the associations between birthweight and lipid levels in middle-age: findings from the 1958 British birth cohort [PDF]
Objective To examine sex differences in birthweight–lipid associations. Methods and results Using prospectively collected data on birthweight and non-fasting lipid levels at age 44–45 y from the 1958 British birth cohort (3603 men and 3583 women ...
Cooper, R., Power, C.
core
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Governance, Social Media and The Cybercitizen – Always in Motion is the Future
This article considers the emerging technologies known as Web 2.0 and how changing technologies may change the way we think about governance. In the last thirty years digital computing has had a transformational effect on the way governments view the ...
Andrew Power
doaj +1 more source
Power and wealth: indicators & trends in the global political economy [PDF]
The aim of this first ‘Power & Wealth’ Report is to kick off a new research project that aims to explore, in a historical perspective, trends in the distribution of wealth and economic power among states and global regions.
Antoniades, Andreas +2 more
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source

