Results 71 to 80 of about 16,330,143 (357)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 2019 Let $ A \subset B$ be rings. An ideal $ J \subset B$ is called power stable in $A$ if $ J^n \cap A = (J\cap A)^n$ for all $ n\geq 1$. Further, $J$ is called ultimately power stable in $A$ if $ J^n \cap A = (J\cap A)^n$ for all $n$ large i.e., $ n \gg 0$. In this note, our focus is to study these concepts for pair of rings $ R \subset R[X]$ where $R$ is
openaire +2 more sources
Mad Men: Dream Come True TV, edited by Gary R. Edgerton
Alphaville: Journal of Film and Screen Media, 2013 In Changing Places, the first instalment of David Lodge’s timeless campus trilogy, Morris Zapp, Professor of English at Euphoria College and doyen of Jane Austen studies, announces his intention to write the definitive examination of the author’s work, a
Aidan Power
doaj +1 more source
Expressing OWL axioms by English sentences: dubious in theory, feasible in practice [PDF]
, 2010 With OWL (Web Ontology Language) established as a standard for encoding ontologies on the Semantic Web, interest has begun to focus on the task of verbalising OWL code in controlled English (or other natural language).
Power, Richard, Third, Allan
core +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Takt complementing Last Planner® System on residential construction projects.
Construction Economics and BuildingIreland is experiencing a national housing crisis, and this is replicated across many developed economies. This challenges governments and housebuilders to increase production whilst balancing challenging human resource and supply chain constraints ...
William Power
doaj +1 more source
Social exclusion and the future of cities [PDF]
, 2000 In both Britain and the United States, people have been moving away from the inner cities to suburban developments, often leaving behind concentrations of poverty and decaying neighbourhoods. Anne Power's paper focuses on the British situation.
Power, Anne, Wilson, William Julius
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source