Results 231 to 240 of about 1,249,189 (325)

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

Resource Allocation Management for Indoor Power-Line Communications Systems [PDF]

, 2007
Nikolaos Papandreou, Theodore Antonakopoulos   +1 more
openalex   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Secure User Pairing and Power Allocation for Downlink Non-Orthogonal Multiple Access against External Eavesdropping. [PDF]

Entropy (Basel)
Li Y, Chen Y, Ji X.
europepmc   +1 more source

A New Decentralized Power Allocation Strategy in Single-Hop Wireless Networks [PDF]

, 2007
Jamshid Abouei, Masoud Ebrahimi, Amir K. Khandani   +2 more
openalex   +1 more source

Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation

Advanced Science, EarlyView.
AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang, Qing Wang, Minghao Zhou, Jialu Liang, Lei You, Breton Asken, Xiaobo Zhou, Qianqian Song   +7 more
wiley   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science, EarlyView.
A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo, Huang Yang, Xiaoming Jiang, Zheng Wang, Xuxiao He, Ying Meng, Shan Li, Min Li, Daqian Xu, Zhengwei Mao, Zhimin Lu   +10 more
wiley   +1 more source

Power Allocation for Discrete-Input Non-Ergodic Block-Fading Channels [PDF]

, 2007
Khoa D. Nguyen, Albert Guillén i Fàbregas, Lars K. Rasmussen   +2 more
openalex   +1 more source

Interpretable Multimodal Fusion Model Enhances Postoperative Recurrence Prediction in Gastric Cancer

Advanced Science, EarlyView.
An interpretable multimodal fusion model (RSA) integrating clinical, radiomic, and pathomic features is developed and validated to predict early postoperative recurrence in gastric cancer. The RSA model demonstrates superior predictive performance and holds potential for guiding adjuvant chemotherapy decisions and improving individualized patient ...
Ping'an Ding, Jiaxuan Yang, Sheng Chen, Honghai Guo, Jiaxiang Wu, Haotian Wu, Li Yang, Wenqian Ma, Yuan Tian, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Yueping Liu, Lingjiao Meng, Qun Zhao   +16 more
wiley   +1 more source