Results 41 to 50 of about 2,254,969 (255)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A high speed truly random number generator based on thermal noise oscilltor

open access: yesDianzi Jishu Yingyong, 2018
A truly random number generator based on thermal noise was proposed, and the resistance thermal noise was used as the noise source of the low frequency clock. It uses two independent working relative relationship between high and low frequency oscillator
Wei Zikui   +9 more
doaj   +1 more source

Power analysis for random‐effects meta‐analysis [PDF]

open access: yesResearch Synthesis Methods, 2017
One of the reasons for the popularity of meta‐analysis is the notion that these analyses will possess more power to detect effects than individual studies. This is inevitably the case under a fixed‐effect model. However, the inclusion of the between‐study variance in the random‐effects model, and the need to estimate this parameter, can have ...
Dan Jackson, Rebecca Turner
openaire   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

An Enhanced Delivery Route Operational Planning Model for Electric Vehicles

open access: yesIEEE Access, 2020
The recent incorporation of Electric Vehicles (EVs) in the worldwide delivery vehicle fleet has increased the importance of their operation in road networks.
Pablo Diaz-Cachinero   +3 more
doaj   +1 more source

HFBN: An Energy Efficient High Performance Hierarchical Interconnection Network for Exascale Supercomputer

open access: yesIEEE Access, 2022
Supercomputers are trying to be eco-friendly using their main components like- interconnection networks, processors, and shared memory through high power efficiency (GFlops/watts).
Faiz Al Faisal   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

A method for on chip capacitor evalueted for capless LDO structure

open access: yesDianzi Jishu Yingyong, 2019
Aiming at the limitation of SOC′s pin number, and in security IC applications, on chip capless LDO and on chip decouple capacitor were preferred for suppling digital cores power.
He Yang   +6 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

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