Results 141 to 150 of about 5,013,725 (298)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Multiple Linear Model Analysis of Indoor Air Quality for Air Conditioning System in Office Building

Chemical Engineering Transactions
The building performance is measured through the power consumption of the air conditioning system and indoor air quality (IAQ) of the building spaces to provide sufficient cooling while at the same time satisfying thermal comfort.
Siti Nur Afifah Noordin Saleem, Nur Izyan Zulkafli, Boon Tuan Tee, Mohamad Firdaus Sukri, Musthafah Mohd Tahir, Asjufri Muhajir, Mohamad Fani Sulaima, Dawid Piotr Hanak   +7 more
doaj  

Research and Development of Commercial Central Air-conditioning Inverter Based on PWM Rectifier

Kongzhi Yu Xinxi Jishu, 2015
It introduced a commercial central air-conditioning inverter based on PWM rectifier, including its principle, power circuit, main parameters and overall structure.
WANG Ting, LIANG Zhiwei, LIU Haitao, YING Ting   +3 more
doaj  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

A Control Strategy of Air-Conditioning Load Groups and Optimization Scheduling as Demand-side Resources Participating in Grid

工程科学与技术, 2017
:At present，the air-conditioning load participates in the demand side management of power grid,and the operation characteristics of the load are in accordance with the fixed frequency.Considering that under the same temperature interval,the number of ...
刘利兵, 刘天琪
doaj  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Ductless task air-conditioning

, 2012
Task-ambient conditioning (TAC) systems have proven success in reducing power consumption, improving thermal comfort and enhancing air quality. However, the adoption of TAC has, however, been generally slow.
Jane Sargison (14748706), Banbury, S (15569405), Law, T (15569402), Mark Fay (14736367)   +3 more
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