Results 61 to 70 of about 5,013,725 (298)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Application of DC Power Supply Air-conditioning Units in Urban Rail Transit Vehicles

Chengshi guidao jiaotong yanjiu
［Objective］ Currently, air-conditioning units in urban rail transit vehicles predominantly use an AC (alternating current) 380 V power supply mode, which requires two power conversions before reaching the end-use equipment, inevitably leading to some ...
KANG Wei, ZHAO Jun, QI Xin, YU Guanglu, CHEN Yuan   +4 more
doaj   +1 more source

Consideration of peak cut method by air conditioning equipment corresponding to demand for contract power reduction—Application of thermal radiative cooling/heating system

Energy Reports, 2020
Electricity demand leveling has actively been pursued in order to reduce power supply costs and reduce carbon dioxide emissions. In addition, large-scale customers have attracted great interest because of the expectation of contract power reduction ...
Akihiro Satake, Junpei Jike, Yasunori Mitani   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Experimental Investigation on the Performance of Household Air Conditioning System with Grid-connected Photovoltaic

Zhileng xuebao, 2015
With the base of traditional air conditioning system, the grid-connected photovoltaic household air conditioning system based on the solar photovoltaic power generation technology is designed in this paper.
Jin Tingxiang, Xu Xiaofeng
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Power conditioning for computers

, 1986
Power conditioning for ...
Parker-Jenkins, Marie, Parker-Jenkins, William   +1 more
openaire   +2 more sources

Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging [PDF]

, 1999
Previous functional neuroimaging studies have characterized brain systems mediating associative learning using classical delay conditioning paradigms.
Buchel, C, Friston, K., Armony, J., Armony, J, Dolan, R, Dolan, R. ; https://orcid.org/, Buchel, C., Friston, K   +7 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source