Results 181 to 190 of about 1,129,017 (245)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

open access: yesAdvanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu   +11 more
wiley   +1 more source

MOKA: a pipeline for multiomics bridged SNP-set kernel association test. [PDF]

open access: yesG3 (Bethesda)
Enoma D   +5 more
europepmc   +1 more source

Non-invasive environmental DNA sampling reveals tuberculosis risks at the human - Great Ape Interface in Africa. [PDF]

open access: yesEmerg Microbes Infect
Kalalizi E   +19 more
europepmc   +1 more source

The Donkey Genome: From Evolutionary Insights to Sustainable Breeding Strategies. [PDF]

open access: yesAnimals (Basel)
Zhu Q   +8 more
europepmc   +1 more source

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