Results 61 to 70 of about 6,036,652 (254)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Risk and Simulation Evaluation of Large-Scale Centralized New Energy Sending System

发电技术, 2018
Large-scale centralized new energy sending system is a unique form of power grid in China. Due to the high proportion of new energy sources and low tolerance to high-voltage direct current(HVDC) fault disturbance, there are prominent problems in the ...
Shiying MA, Qing WANG
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Analysis and Experimental Verification of New Power Flow Control for Grid-Connected Inverter with LCL Filter in Microgrid

The Scientific World Journal, 2014
Microgrid is an effective way to integrate the distributed energy resources into the utility networks. One of the most important issues is the power flow control of grid-connected voltage-source inverter in microgrid.
Herong Gu, Yajuan Guan, Huaibao Wang, Baoze Wei, Xiaoqiang Guo   +4 more
doaj   +1 more source

Wide-Area Measurement—Based Model-Free Approach for Online Power System Transient Stability Assessment

Energies, 2018
Online assessment of transient stability of power systems is critical for avoiding blackout. The increasing installation of phasor measurement units in power systems and the advancement of the wide-area measurement systems make it possible to develop ...
Dan Huang, Qiyu Chen, Shiying Ma, Yichi Zhang, Shuyong Chen   +4 more
doaj   +1 more source

The nature and role of experiential knowledge for environmental conservation [PDF]

, 2010
Understanding the nature and role of experiential knowledge for environmental conservation is a necessary step towards understanding if it should be used and how it might be applied with other types of knowledge in an evidence-based approach.
Fazey, Ioan Raymond Albert, Lindenmayer, David B., Dovers, Steve, Fazey, John A., Salisbury, Janet G.   +4 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

New Power Sharing Control for Inverter-Dominated Microgrid Based on Impedance Match Concept

The Scientific World Journal, 2013
Power flow control is one of the most important issues for operating the inverter-dominated autonomous microgrid. A technical challenge is how to achieve the accurate active/reactive power sharing of inverters. P-F and Q-V droop control schemes have been
Herong Gu, Deyu Wang, Hong Shen, Wei Zhao, Xiaoqiang Guo   +4 more
doaj   +1 more source