Results 121 to 130 of about 18,114,759 (305)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Vulnerability and risk assessment of power distribution networks under typhoon compound hazards: a case study of Fujian Province China

Environmental Research Letters
Typhoon compound wind-precipitation disasters (TCWPD) pose a significant threat to distribution network infrastructure, triggering cascading socioeconomic impacts through widespread power outages.
Hao Chen, Nai-Xuan Zhu, Mei Mei, Hai-Xu Hong, Nuo-Ling Sun, Guo-Fu Wang   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Multi-Timescale Scheduling Optimization of ALK/PEM Hybrid Electrolyzers System Considering Flexible Hydrogen Demand

Engineering
Hydrogen production from renewable energy is a promising solution for clean and efficient hydrogen generation. The hybrid electrolyzers system (HES) consists of alkaline (ALK) and proton exchange membrane (PEM) electrolyzers.
Bowen Wang, Zhaoqing Liang, Kai Yang, Lei Xing, Heng Shao, Zhuorui Wu, Yixin Liu, Li Guo, Ning Yang, Bing Hu, Chengshan Wang, Kui Jiao   +11 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Stochastic‐gradient‐based control algorithms for power quality enhancement in solar photovoltaic interfaced three‐phase distribution system

IET Generation, Transmission & Distribution
Here, stochastic‐gradient‐based adaptive control algorithms have been discussed and employed for power quality enhancement in a Photovoltaics (PV) integrated distribution system.
Dinanath Prasad, Narendra Kumar, Rakhi Sharma, Majed A. Alotaibi, Hasmat Malik, Fausto Pedro García Márquez, Mohammad Asef Hossaini   +6 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Distributed optimization control strategy for distribution network based on the cooperation of distributed generations

IET Renewable Power Generation
Aiming to improve the voltage distribution and realize the proportional sharing of active and reactive power in the distribution network (DN), this article proposes a distributed optimal control strategy based on the grouping cooperation mechanism of the
Dong Hua, Suisheng Liu, Yiqing Liu, Jian Le, Qian Zhou   +4 more
doaj   +1 more source