Results 31 to 40 of about 231,762 (266)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Early Flame and Smoke Detection in Valve Halls of Ultra-High-Voltage Converter Stations Using an Attention-Enhanced YOLOv5s Model

Fire
Early detection of incipient fire signs, such as dilute smoke emerging at valve hall penetration seals, remains a critical challenge for fire safety in ultra-high-voltage (UHV) converter stations.
Rui Liu, Jia Xie, Hanbing Hao, Taiyun Zhu, Yi Guo, Xiang Liu, Yang He, Jiaqing Zhang, Tianchang Meng   +8 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Influence of Flexibilizers on the Thermal and Combustion Properties of Soundproof Enclosures in Ultrahigh Voltage Converter Transformer Equipment

Fire
Soundproof enclosures are essential components in ultra-high voltage converter transformer equipment. However, conventional designs pose considerable fire risks, as they may impede fire suppression efforts in case of equipment failure. This study adopted
Jiaqing Zhang, Fengju Shang, Yi Guo, Wenlong Zhang, Yanming Ding   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Experimental study on enhancing the foam spray range of compressed air foam nozzle

Journal of Safety Science and Resilience
As the core equipment in power systems, ultra-high voltage (UHV) transformers pose a high fire risk. The compressed-air foam spray nozzle is a novel end-release device that, due to its high efficiency and excellent suppression effect on oil-based fires ...
Fengju Shang, Jiaqing Zhang, Xin Liu, Yi Guo, Yunpeng Yang, Lilong Nie, Kaiyuan Li   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of oil immersion on the horizontal flame spread over transformer insulating paperboard with different sizes

Case Studies in Thermal Engineering
Transformer oil and insulating paperboard are widely used in oil-immersed transformers and may be ignited in the event of device failure. The present study aims to investigate the effect of oil immersion on the horizontal flame spread over the ...
Yubiao Huang, Yi Guo, Fengju Shang, Jiaqing Zhang   +3 more
doaj   +1 more source

Analysis of Distribution Network Protection Based on Distributed Power Sources

IOP Conference Series: Materials Science and Engineering, 2018
After a distributed power supply is connected to a distribution network, the distribution network changes from a single-supply radiant network to a network. When a fault occurs in the distribution network, the size and direction of the short - circuit current will change, giving rise to conventional relay protection. Normal operation brings a series of
Rili Cong, Shuai Ji, Mingyu Zhao, Chun Pang   +3 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source