Results 51 to 60 of about 25,369,668 (289)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Polydopamine-Modified Boron Nitride Reinforced Silicone Gel Composites with Enhanced Thermal Conductivity and Electrical Insulation Performance

Gels
Silicone gel (SG) is widely used as a soft encapsulation material for high-voltage power devices because of its excellent flexibility, thermal stability, and electrical insulation. However, its intrinsically low thermal conductivity and susceptibility to
Mengjia Feng, Chaoyue Zhao, Wenbo Li, Xinfeng Lv, Zichen Cui, Jianzeng Guo, Mai Hao   +6 more
doaj   +1 more source

An Environmental-Economic Dispatch Method for Smart Microgrids Using VSS_QGA

Journal of Applied Mathematics, 2014
The increasing penetration of distributed generation resources demands better economic performance of microgrids under the smart-grid era. In this paper, a comprehensive environmental-economic dispatch method for smart microgrids is proposed, with the ...
Wenxia Liu, Yuying Zhang, Bo Zeng, Shuya Niu, Jianhua Zhang, Yong Xiao   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Optimal decision method of demand side flexible resources as power system operation reserve based on master–slave game

International Journal of Electrical Power & Energy Systems
The escalating penetration of renewables and simultaneous source–load uncertainties are critically eroding reserve margins in modern power systems, leaving the latent flexibility of demand-side resources largely untapped.
Xiangyu Kong, Yang Lv, Zhiduan Yang, Yue Guo, Longyu Zhang, Gaohua Liu   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enhanced Fault Localization for Active Distribution Networks via Robust Three-Phase State Estimation

Energies
Accurate fault localization is critical for ensuring reliable power supply in active distribution networks, yet conventional state estimation (SE)-based methods fail to differentiate authentic fault responses from measurement distortions due to ...
Guorun He, Dong Liang, Yuezi Zhao, Xiaoxue Wang   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Distributed adaptive resilient control for AC microgrids against false data injection attacks on state information

Frontiers in Energy Research
In AC microgrids interconnected through a flexible DC system, false data injection attacks (FDIAs) targeting the control process of AC/DC converters may cause state deviations and even loss of synchronization among microgrids.
Yansong Zhao, Qian Xiao, Wenbiao Lu, Shiwen Su, Wenlu Ji, Jiannan Zhang, Zijian Hu   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source