Results 101 to 110 of about 8,930,007 (301)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Distribution Optimal Power Flow

open access: yes, 2007
This paper presents a new and efficient methodology for network reconfiguration with optimal power flow based on Benders Decomposition approach. The objective minimizes the power losses, balancing load among the feeders and subject to the constraints ...
H. M. Khodr, J. Pereira, M. A. Matos
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Study on Thermal Radiation Characteristics and the Multi-Point Source Model of Hydrogen Jet Fire

open access: yesApplied Sciences
Hydrogen safety remains a paramount concern in pipeline transportation. Once hydrogen leaks and ignites, it quickly escalates into a jet fire incident. The substantial thermal radiation released poses significant risks of fire and explosion.
Haiyang Zhang   +8 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Tuning Ag Loading and Particle Size in Ag@g-C3N4 Photocatalysts for Selective CO2 Conversion to CO and CH4

open access: yesNanomaterials
Elucidating the mechanisms of CO2 photocatalytic conversion systems is crucial for tackling the challenges of carbon neutrality. In this study, a series of Ag@g-C3N4 photocatalysts were constructed with metal particle size modulation as the core strategy
Shicheng Liu, Na Li, Qulan Zhou
doaj   +1 more source

Development of carbon coated membrane for zincbromine flow battery with high power density

open access: yes, 2013
Development of carbon coated membrane for zincbromine flow battery with high power ...
程元徽   +4 more
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

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