Results 101 to 110 of about 943,514 (317)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Geothermal Power Generation as Related to Resource Requirements

, 1982
For the past several years geothermal exploratory work has been conducted in northern Nevada. In conjunction with that effort a proposed 55-MW steam geothermal power plant was considered for initial installation in one of the fields being developed.
Richards, R. G., Keilman, L. R., Falcon, J. A.   +2 more
core  

Frequency control by variable speed wind turbines in islanded power systems with various generation mix

, 2017
This study presents the impact on power system frequency control in small power systems based on different generator topologies with a large penetration (50%) of variable speed wind turbines.
Persson, Mattias, Chen, Peiyuan, Persson, Mattias,, Chen, Peiyuan,   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Assessment of novel power generation systems for the biomass industry [PDF]

, 1999
The objective of this programme of research is to produce a method for assessing and optimising the performance of advanced gas turbine power plants for electricity generation within the Brazilian electric sector.
Codeceira Neto, A., Codeceira Neto, Alcides   +1 more
core  

Power quality comprehensive evaluation based on combination weighting method

, 2012
Power quality problems have drawn extensive attention in recent years, from both power companies and customers. Reliable and comprehensive evaluation of power quality, as one of current research focuses, possesses great significance in assessing power ...
Zhai, Xingli, J.S. Huang, F.S. Wen, Wen, Fushuan, Huang, Jiansheng (R9337), X.L. Zhai, Z.Z. Lin, Lin, Zhengzhi   +7 more
core   +1 more source

Digital Twin Technology for Smart Power Generation and Its Application Modes

, 2020
As an important part of power system, the intelligent construction of power generation process is an important direction to promote the development of energy transformation in China.
Dongyang LIANG, Xiaoning ZHANG, Fang FANG, Qinghua WANG   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source