Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
GA/SA-based hybrid techniques for the scheduling of generator maintenance in power systems [PDF]
, 2000 YesProposes the application of a genetic algorithm (GA) and simulated annealing (SA) based hybrid approach for the scheduling of generator maintenance in power systems using an integer representation.
Galloway, S.J. +8 more
core +1 more source
Research on New Energy Generation Scheduling for Grid Security and Scheduling Fairness
南方能源建设, 2021 [Introduction] With incessant grid-connection of wind farms and photovoltaic power stations, the development of regional power grid structure cannot keep pace with the growth rate of new energy unit capacity, characteristics of multi-energy mix and ...
GUO Yuanping +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Multi-objective Optimal Scheduling of Water-Carbon in Cascade Reservoirs during Impoundment for Carbon Emission Reduction [PDF]
长江科学院院报[Objectives] This study aims to optimize water-carbon coordinated scheduling during reservoir impoundment to improve power generation and storage rate, and to reduce greenhouse gas emissions in reservoir operation. [Methods] Given that current studies on
ZHOU Yan-lai, NING Zhi-hao, HE Jun-tao
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Short-term generation scheduling in a hydrothermal power system. [PDF]
, 1990 SIGLEAvailable from British Library Document Supply Centre- DSC:D173872 / BLDSC - British Library Document Supply CentreGBUnited ...
Xiong, Min, Xiong, M
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source