Results 91 to 100 of about 13,571,323 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Experimental Investigation of the Yaw Misalignment Effect on the Power Performance and System Loading of a Flapping‐Foil Hydrokinetic Turbine

Energy Science & Engineering
Hydrokinetic turbines (HTs) extract power by utilizing hydrodynamic forces from flow energy. The surplus load not used for power generation acts as a system load and must be considered when designing the turbine.
Dong‐Geon Kim, Jihoon Kim, Sejin Jung, Jin Hwan Ko   +3 more
doaj   +1 more source

Impact of wind power on the unit commitment, operating reserves and market design [PDF]

, 2011
Paper presented at the 2011 IEEE Power and Energy Society General Meeting, San Diego, CA, 24-29 July 2011This article highlights and demonstrates the new requirements variable and partly unpredictable wind power will bring to unit commitment and power ...
Milligan, M., Lange, B., Gibescu, M., Michael Milligan, Hannele Holttinen, Lange, Bernard, Kiviluoma, K., Juha Kiviluoma, Meibom, P., Meibom, Peter, O\u27Malley, Mark, Peter Meibom, Madeleine Gibescu, Kiviluoma, Juha; id_orcid, Tuohy, Aidan, Holttinen, H., Tuohy, A., Gibescu, Madeleine, Holttinen, Hannele, O'Malley, M., Milligan, Michael R., Bernhard Lange, Kiviluoma, Juha, Aidan Tuohy, O'Malley, Mark, Mark O'Malley, Kiviluoma, J.   +26 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Physical Profile of Strongman and Strongwoman Athletes

International Journal of Strength and Conditioning
While strongmen and strongwomen are among the strongest athletes in all sports, limited literature is available pertaining to the physical and physiological characteristics of this population, including their vertical jump ability.
Yang Yang, Quincy Johnson, Nicolas Philipp, Drake Eserhaut, Joe Kenn, Dimitrije Cabarkapa, Andrew Fry   +6 more
doaj   +1 more source

Operation strategies and performance of air-conditioning systems with thermal energy storage in power systems

, 2016
Energy storage is one of the most effective measures to overcome the challenges from the massive integration of renewable energy sources (RESs) with high uncertainty. However, there still lacks inexpensive and feasible choices of energy storage for power
Tang, Y, Zhong, J, Yuchen Tang, Jin Zhong   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Tip-rem modification for full tooth surface pattern and require no edge contact of high loaded capacity cycloidal hypoid gears

Xibei Gongye Daxue Xuebao
The full tooth surface pattern and require no edge contact design of cycloid bevel gears based on Tip-rem is a novel gear optimization design method, which aimed at optimizing contact performance of gears and preventing edge contact, thus improving the ...
Tan Zong, Deng Xiongyao, Li Guowen, Zhou Zhenyu, Rong Shifeng, Tang Jinyuan, Yang Yudian, Yao Wenlong, Ding Han   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source