Results 31 to 40 of about 849,936 (315)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hydrologic regime alteration and influence factors in the Jialing River of the Yangtze River, China

Scientific Reports, 2022
Under the influence of climate alteration and human activities, the hydrological regime of rivers is changing dramatically, which has become a hot spot for water environment research.
Wenxian Guo, Xuyang Jiao, Haotong Zhou, Yongwei Zhu, Hongxiang Wang   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Power resources and supranational mechanisms: The global unions and the OECD Guidelines

, 2021
This article uses the power resources approach to analyse the Global Union Federations’ (GUFs) use of the specific instances mechanism associated with the OECD Guidelines for Multinational Enterprises. While this mechanism has serious limitations, it has
Ford, Michele, Gillan, Michael
core   +1 more source

Temporal and Spatial Variations in Landscape Habitat Quality under Multiple Land-Use/Land-Cover Scenarios Based on the PLUS-InVEST Model in the Yangtze River Basin, China

Land, 2023
Despite the Yangtze River Basin (YRB)’s abundant land and forestry resources, there is still a dearth of research on forecasting habitat quality changes resulting from various geographic and environmental factors that drive landscape transformations ...
Ning He, Wenxian Guo, Hongxiang Wang, Long Yu, Siyuan Cheng, Lintong Huang, Xuyang Jiao, Wenxiong Chen, Haotong Zhou   +8 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Reviewing an efficiency of the use of fuel and power resources for the industry of Ukraine [PDF]

, 2017
Розглянуті актуальні питання щодо проблеми ефективного використання та споживання паливно-енергетичних ресурсів в промисловості Україні. Наведенні приклади пошуку технічних рішень, які можуть знизити собівартість теплової та електричної енергії. Наведені
Дягілєв, Вадим Олександрович, Кавєрцєв, Валерій Леонідович   +1 more
core   +1 more source

Engineering Evaluation of Microbe-Material Synergistic In-situ Remediation for Campus Landscape Lakes [PDF]

E3S Web of Conferences
Campus landscape lakes are vulnerable to combined organic and nutrient pollution because of weak hydrodynamics and limited self-purification capacity. Conventional in-situ remediation often suffers from rapid material loss and short treatment duration ...
Wang Zhuoran, Liang Dan, Li Rujia, Peng Cong, Liu Decai   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source