Results 71 to 80 of about 10,176,069 (259)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
An efficient parallel runoff forecasting model for capturing global and local feature information
Scientific ReportsArtificial intelligence has significantly accelerated the development of hydrological forecasting. However, research on how to efficiently identify the physical characteristics of runoff sequences and develop forecasting models that simultaneously ...
Yang-hao Hong +5 more
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
The axial tip clearance leakage analysis of the squealer blade tip for the liquid-ring pump
Scientific ReportsThe gas-liquid two phase leakage flow in the clearance of Liquid ring pump has severe negative impact on its hydraulic performance. In order to analyze the flow structure of leakage flow and suppress it, the squealer blade tip was introduced to Liquid ...
Xiaoxiao Wei +4 more
doaj +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Estimate of cost of power at the proposed fresh water lake; 1934
, 1931 Series 1173 | State Planning Board | Power resources records | Estimate of cost of power at the proposed fresh water lake; 1934One of the duties of the State Planning Board was to plan for the conservation and development of the natural resources of the ...
State Planning Board
core
Influence of path materials on rock avalanche dynamics in the Nayong case study
Scientific ReportsRock avalanches are highly destructive geological hazards marked by sudden onset, rapid acceleration, and substantial material entrainment. These characteristics render the investigation of their kinematic processes particularly challenging and complex ...
Xu Sheng Zhang +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
Power Data- collection of reports; Electrical energy cost data
, 1931 Series 1173 | State Planning Board | Power resources records | Power Data- collection of reports; Electrical energy cost dataOne of the duties of the State Planning Board was to plan for the conservation and development of the natural resources of the ...
State Planning Board
core
Scientific ReportsThe People’s Victory Canal irrigation area is an important agricultural irrigation region in the North China Plain, where groundwater resources play a crucial role in both agricultural production and the ecological environment.
Zhongpei Liu +5 more
doaj +1 more source