Results 51 to 60 of about 33,116 (304)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

On λ-rings and topological realization

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2006
It is shown that most possibly truncated power series rings admit uncountably many filtered λ-ring structures. The question of how many of these filtered λ-ring structures are topologically realizable by the K-theory of torsion-free spaces is also ...
Donald Yau
doaj   +1 more source

Right Gaussian rings and skew power series rings

open access: yesJournal of Algebra, 2011
The authors extend the notion of a Gaussian ring to a noncommutative setting by introducing right Gaussian rings. For a ring \(R\) and a polynomial \(f\in R[x]\), let \(c_r(f)\) be the right ideal of \(R\) generated by the coefficients of \(f\). If \(c_r(fg)=c_r(f)c_r(g)\) for any \(f,g\in R[x]\), the ring \(R\) is called `right Gaussian'.
Mazurek, Ryszard, Ziembowski, Michał
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Localizations and completions of skew power series rings

open access: yesAmerican Journal of Mathematics, 2010
This paper is a natural continuation of the study of skew power series rings $A=R[[t;\sigma,\delta]]$ initiated in an earlier work. We construct skew Laurent series rings $B$ and show the existence of some canonical Ore sets $S$ for the skew power series rings $A$ such that a certain completion of the localization $A_S$ is isomorphic to $B.$ This
P. Schneider, O. Venjakob
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Seminormality in power series rings

open access: yesJournal of Algebra, 1983
Let R be a commutative unitary ring. Recently, several authors have been interested in the preservation of seminormality in passing from R to the polynomial ring R [X, ,..., X,,J. In this paper we give a proof in the case of power series rings and the proof is both short and applicable in the polynomial setting.
Brewer, J.W, Nichols, Warren D
openaire   +2 more sources

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