Results 221 to 230 of about 5,161,755 (306)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A low-cost modular PCB assembly for functional and in-circuit testing. [PDF]

HardwareX
Puentes-Conde GM, Sifuentes E, Molina J, Enríquez-Aguilera F, Bravo G, Ávila AH.   +5 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Review and assessment of policies and practices for spinal cord injury-related health care supplies, services, and mobility equipment reveal wide inequities and inadequacies in Canada. [PDF]

Front Public Health
Warkentin PB, Gregory JH, Athanasopoulos P, Ripat J, Cowley KC.   +4 more
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

A dataset of corona inception and complete breakdown for sub-atmospheric air under alternating and direct current supply. [PDF]

Sci Data
Riba JR, Soltany M.
europepmc   +1 more source

Correspondence Principle Approach to Time-Dependent Decaying Quantized Fields. [PDF]

Entropy (Basel)
Ramos-Prieto I, Korneev N, Moya-Cessa HM.   +2 more
europepmc   +1 more source

Famine Foods: A Structured Narrative Review of Nutritional, Toxicological, Ecological, and Socio-Cultural Perspectives. [PDF]

Foods
Guil Guerrero JL, Heras-Roger JEL, Rincón-Cervera MÁ, Díaz-Romero C.   +3 more
europepmc   +1 more source

A Nature-Inspired Hybrid Heuristic for Orchestrating the Self-Deployment of Mobile Supply Robots in Communication-Contested Environments. [PDF]

Biomimetics (Basel)
Saffre F, Hildmann H.
europepmc   +1 more source