Results 81 to 90 of about 6,662,811 (306)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Data-driven residential electricity load forecasting method for virtual power plants

Journal of Engineering and Applied Science
Virtual power plants (VPP) integrate distributed energy resources and residential loads to enhance the flexibility and reliability of power systems. Accurate residential electricity load forecasting is therefore essential for VPP scheduling and demand ...
Wenbin Hao, Bo Xie, Zhigao Meng, Huanhuan Li, Yan Tu, Qinlu Fang, Jing Xue, Yiming Hu   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Electromagnetic interference in complex power supply networks [PDF]

, 2010
The power supply electromagnetic interference (EM!) phenomena are strongly related to power quality (PQ). Power quality is conventionally related to the quality of supply in terms of fast voltage variations (sags, surges), slow variations (flicker) and ...
Cuk, V., Timens, R.B., Leferink, Frank Bernardus Johannes; id_orcid, Timens, RB, Melenhorst, M., Cobben, J.F.G., Buesink, FJK, Kling, WL Wil, Leferink, F.B.J., Leferink, FBJ Frank, Leferink, Frank Bernardus Johannes, Buesink, Frederik Johannes Karel, Cobben, JFG Sjef, Buesink, F.J.K., Melenhorst, M, Cuk, V Vladimir, Kling, W.L.   +16 more
core  

Cell-level power supply for high-voltage modular multilevel converters

, 2017
Focus is on the design and development of an auxiliary power supply converter for HVDC and FACTS applications, utilising integrated gate-commutated thyristors.
Blinov, Andrei,, Gabriel Tibola, Tibola, Gabriel, Blinov, Andrei, Staffan Norrga, Velotto, Giovanni, Norrga, Staffan, Norrga, Staffan,, Giovanni Velotto, Tibola, Gabriel; id_orcid, Andrei Blinov   +10 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Design of low-power algorithm for intelligent meter reading network based on improved LEACH protocol

Discover Applied Sciences
The development of smart grids requires smart meter reading and metering networks to support large-scale, low-power, and real-time data collection on the user side.
Kehuan Wen, Yubo Zhang, Xiangyong Yang, Shihong Yin   +3 more
doaj   +1 more source