Results 91 to 100 of about 191,823 (301)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
RELIABILITY AND QUALITY OF THE POWER SUPPLY FOR RAIL TRANSPORT
Scientific Journal of Silesian University of Technology. Series Transport, 2017 The subject of this paper deals with the reliability of the power supply and quality of electricity on the railway networks. The paper discusses the impact of changes in the area of traction substation load on parameters characterizing the quality of ...
Zbigniew OLCZYKOWSKI +2 more
doaj +1 more source
, 2011 [[abstract]]In many countries, electric utilities are state-owned enterprises, the purpose of public investment in the provision of basic of public services to support economic development. Taiwan Power Company is a state-owned enterprises.
Chen-Pan Lin
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Wind farm optimun efficiency by voltage control
, 2007 Publisher Copyright: © 2007, European Association for the Development of Renewable Energy, Environment and Power Quality (EA4EPQ). All rights reserved.The basic idea of improving both the power factor and the efficiency of induction motors at partial or ...
Payán, M. Burgos +8 more
core +1 more source
Modelling the supply chain perception gaps [PDF]
, 2013 This study applies the research of perception gap analysis to supply chain integration and develops a generic model, the 3-Level Gaps Model, with the goal of contributing to harmonization and integration in the supply chain.
Lu, Dawei, Betts, Alan, Ertek, Gürdal
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjective In the DC (direct current) traction power supply system of urban rail transit, excessive rail potential and stray current issues are persistent problems and common ailments for operational routes.
TANG Zhaojun +5 more
doaj +1 more source