Results 181 to 190 of about 12,617,022 (288)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Evaluation of surveillance performance and determinants for priority vaccine-preventable diseases in Niger State, Nigeria: A CDC 2001 Guideline-based multilevel analysis. [PDF]

PLOS Glob Public Health
Awoyale OD, Jimoh A, Dede A, Rauf RI, Mustafa A, Sowade TA, Gimba PB, Ibrahim I, Akpen CN, Eugene EC, Erekosima GF, Okekeigwe C, Tarfa MJ, Isiaka SD, Okagbue H, Atobatele S, Sampson S.   +16 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

From cognitive overload to institutional escalation: formalizing the supply-demand production condition in patient-safety failure. [PDF]

Front Health Serv
Mikkelsen Y.
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Unintended consequences of National centralized volume-based drug procurement policy in China: a game theory-based analytical approach for pharmaceutical quality and pricing. [PDF]

Cost Eff Resour Alloc
Zhang S, Li J, Li S, Li J, Zhang L, Wang R, Chen C, Zhu L.   +7 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Optimized PI based fuzzy controller for power quality assessment in autonomous microgrid using novel hybrid bio-inspired optimization technique. [PDF]

Sci Rep
Govindasamy S, Selvaraj J, Angamuthu R, Azerefegn TM.   +3 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

From carbon cost to climate care: Greening our intensive care units. [PDF]

World J Crit Care Med
Goel S, Kataria S, Juneja D.
europepmc   +1 more source