Results 111 to 120 of about 2,387,122 (349)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Fault diagnosis of the constant current remote power supply system in CUINs based on the improved water cycle algorithm

, 2021

openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Analytical Target Cascading Based Active Distribution Network Level Multi-agent Autonomous Collaborative Optimization

Zhongguo dianli
As part of the strategic push toward achieving carbon neutrality, the imperative to integrate renewable energy into active distribution networks (ADNs) on a large scale has become a priority.
Jiawu WANG, Dianyun ZHAO, Changfeng LIU, Kang CHEN, Yumin ZHANG   +4 more
doaj   +1 more source

Model predictive control of VSC-HVDC transmission system for power supply to passive networks [PDF]

, 2019
Pengfei Zhao, Mingxing Guo, Xiaojun Tang, Yingpei Liu, Qidi Huo, Aili Pang, Mengyao Zhang, Sizhuo Lv   +7 more
openalex   +1 more source

Method of Forming a Volt-Amper Characteristic of a Solar Array Simulator for Testing Power Supply Systems of Spacecraft [PDF]

, 2020
O. G. Rekutov, Anton Yudintsev
openalex   +1 more source

Study of the pulse power supply unit for the four-horn system of the CERN to Frejus neutrino super beam

, 2013
The power supply studies for the four-horn system for the CERN to Fr\'ejus neutrino Super Beam oscillation experiment are discussed here. The power supply is being studied to meet the physics potential and the mega-watt (MW) power requirements of the ...
Baussan, E, Bouquerel, E, Dracos, M, Gaudiot, G, Osswald, F, Poussot, P, Vassilopoulos, N, Wurtz, J, Zeter, V   +8 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source