Results 51 to 60 of about 270,159 (269)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Multi-Level Dynamic Weight Optimization Scheduling Strategy for Flexible Interconnected Distribution Substations Based on Three-Port SNOPs

Energies
By using a soft normal open point (SNOP) to connect multiple distribution networks to form a flexible interconnected distribution system (FIDS), the power distribution can be flexibly and controllably regulated among distribution stations, but it is also
Dan Pang, Zhipeng Wang, Xiaomeng Shi, Jinming Ge, Zhenhao Wang, Hongyin Yi, Yan Zhuang, Yu Yin, Wei Wang   +8 more
doaj   +1 more source

Tri‐layer low‐carbon distributed optimization of integrated energy systems based on hybrid games under stochastic scenarios

IET Generation, Transmission & Distribution, 2023
The low‐carbon development of integrated energy systems is achieved via the sharing of multiple energy interactions by park‐level IES (PIES).However, coordinating profit distribution conflicts among complex interactive stakeholders in stochastic ...
Ziyi Yue, Huazhi Liu, Yonggang Li, Yuyao Zhong, Jiachen Yao, Yuxuan Li   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Spare Analysis of Transformers Based on Reliability Criterion and Insulation Age Evaluation

Zhongguo dianli, 2019
In view of the fact that the traditional spare analysis methods for transformers does not take into account the actual aging failures of transformers, in this paper, based on reliability criterion and insulation age evaluation, a spare analysis method ...
Bo XIANG, Yunpeng JIANG, Zhouyang REN, Hui LI, Weinan HU, Congyu ZHANG   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Partial Discharge Data Augmentation and Pattern Recognition Method Based on DAE-GAN

Algorithms
Accurate identification of partial discharge (PD) and its types is essential for assessing the operating conditions of electrical equipment. To enhance PD pattern recognition under imbalanced and limited sample conditions, a method based on a Deep ...
Xin Du, Jun Qi, Jiyi Kang, Zezhong Sun, Chunxin Wang, Jun Xie   +5 more
doaj   +1 more source