Results 81 to 90 of about 2,387,122 (349)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

A Virtual Power Plant-Integrated Proactive Voltage Regulation Framework for Urban Distribution Networks: Enhanced Termite Life Cycle Optimization Algorithm and Dynamic Coordination

open access: yesAlgorithms
Amid global decarbonization mandates, urban distribution networks (UDNs) face escalating voltage volatility due to proliferating distributed energy resources (DERs) and emerging loads (e.g., 5G base stations and data centers). While virtual power plants (
Yonglin Li   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Research of arc extinguishing characteristics of annular multi-break compression lightning protection devices [PDF]

open access: yesAIP Advances
The plasma arc generated by lightning strikes is the primary factor causing short circuits in transmission lines. To reduce the lightning-induced trip-out rate of transmission lines, this paper proposes a novel annular multi-break compression active arc ...
Wei Guo   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

An Optimized Method for Setting Relay Protection in Distributed PV Distribution Networks Based on an Improved Osprey Algorithm

open access: yesEnergies
The high penetration of distributed photovoltaics (PV) into distribution networks alters the system’s short-circuit current characteristics, posing risks of maloperation and failure-to-operate to conventional inverse-time overcurrent protection. Based on
Zhongduo Chen   +8 more
doaj   +1 more source

Home - About - Disclaimer - Privacy