Results 81 to 90 of about 2,724,825 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analytical‐Numerical Hybrid Solution for Transient Thermal Analysis of the Outer Gate IGCT Considering Electrical‐Thermal Coupling

IET Power Electronics
The integrated‐gate commutated thyristor (IGCT), known for its low conduction losses and high reliability, is increasingly favoured in high‐voltage and high‐power applications. The junction temperature is a critical determinant of reliability, making the
Naihang Lyu, Yan Pan, Xiaoguang Wei, Xiang Cui, Zhongkang Lin, Kefan Yu, Xinling Tang, Jingfei Wang   +7 more
doaj   +1 more source

Airworthiness study on civil aircraft engine operating characteristics

Hangkong gongcheng jinzhan
Engine operating characteristics of civil aircraft engines are one of the most basic and complex verification subjects in the airworthiness certification process of the Part 25 "airworthiness standard for transport aircraft" of China civil aviation ...
DENG Tianze, YANG Fei, ZHU Yan, QIU Jian, ZHONG Weixing   +4 more
doaj   +1 more source

Blackout and blackstart on power systems

Pressacademia, 2017
Power systems are complex structures that energy production, transmission and consumption units. There are various reasons for energy interruptions on these systems. Power outage on the power system can lead to partial or complete loss of the network. Energy interruptions in large regions cause significant economic losses and precautions must be taken ...
Ayhanci, Cihan, Yoldas, Beyazit Yasar, Kekezoglu, Bedri   +2 more
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The role of power system flexibility in generation planning

, 2011
Paper presented at the IEEE 2011, Power and Energy Society General Meeting, San Diego, CA, 24-29 July 2011As the penetration of variable renewable generation increases in power systems worldwide, planning for the effects of variability will become more ...
Eamonn Lannoye, Lannoye, Eamonn, O\u27Malley, Mark, O'Malley, Mark, Mark O'Malley, Flynn, Damian, Damian Flynn   +6 more
core   +1 more source

Power System Transient Stability Assessment Using Stacked Autoencoder and Voting Ensemble

, 2021
Increased integration of renewable energy sources brings new challenges to the secure and stable power system operation. Operational challenges emanating from the reduced system inertia, in particular, will have important repercussions on the power ...
Antonijo Kunac, Marin Despalatovic, Petar Sarajcev, Goran Petrovic   +3 more
core   +1 more source

Investigation of Quantitative Assessment Techniques for Supply-Regulation Capability in Multi-Scenario New-Type Power Systems

EAI Endorsed Transactions on Energy Web
This paper offers an in-depth investigation into various quantitative assessment methods used to quantify the supply regulation capacity in new types of power systems under different conditions.
Miao Liu, Zesen Wang, Guangming Xin, Qi Li, Shuaihao Kong   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Preliminary environmental assessment for the satellite power system (SPS).

, 1980
January 1980."DOE/NASA satellite power system, concept development and evaluation program."Includes bibliographical references.v. 1. Executive summary.--v. 2.
United States. Satellite Power System Project Office.
core